Muscular Dystrophy: Methods and Protocols (Methods in Molecular Medicine) (Methods in Molecular... by Katherine M.D. Bushand Louise V.B. Anderson Sales Rank: 2148113 List Price: $125.00 $125.00 At Amazon on 9-5-2008.

Hardcover: 472 pages Publisher: Humana Press; 1 edition March 1, 2001 Language: English ISBN-10: 0896036952 ISBN-13: 978-0896036956 Product Dimensions: 9.3 x 6.4 x 1.2 inches Shipping Weight: 2.1 pounds Product Review "This book will be of primary interest to pathologists, geneticists, and neurologists actively engaged in molecular testing of the patients with muscular dystrophy. . .This is a highly practical book aimed at scientists actively engaged in doing the molecular tests. Diseases covered include the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. Both DNA and protein methods are covered. Concluding chapters discuss gene therapy and animal models of muscular dystrophy."-Doody's Health Sciences Book Review Journal "Several of the authors have been major players in making it all possible. It is remarkable to observe how many of the scientific discoveries have had immediate impact on molecular testing and thus have benefited many families through more accurate diagnoses and counseling.After a well-written background section, a major portion of the book deals with the molecular approach to X-linked DMDOutstanding multiplex and Southern procedures are described in great detail, with primer sequences and maps of the restriction fragment patterns provided.Carrier testing, prenatal testing, and genetic counseling are also well covered in the remaining chapters dealing with DMD.The last major section of the book deals with protocols for testing the protein products of several of the dystrophies described earlier. This is an excellent addition because there are often times where the protein analysis is not only supportive but is the definitive test for an accurate diagnosis. Both immunocytochemical and Western immunoblotting are described. I have little doubt that this book will be of great interest and a reference text for laboratory directors specifically involved in muscular dystrophy testing. The techniques are described in great detail with excellent figures. This book will also be of interest to the clinical neurologists who often encounter these disorders. The editors have provided a comprehensive account of not only the methods, but also the clinical utilities of the methods." - Clinical Chemistry "this book certainly lives up to the back-cover hype ("comprehensive and highly practical"; "offersan authoritative collection of tools"). I was particularly impressed by the emphasis on the limitations of each technique, directions for interpretation, important controls and the level of rigor required in a diagnostic setting. The chosen authors are almost without exception recognized as first-rate practitioners of their respective techniques. Their distilled wisdom, the microlitre-by-microlitre protocols, and the tried-and-tested primer sequences (well over 800) make this book an almost sufficient guide to the de novo establishment of a muscular dystrophy diagnostic lab." - Human Genetics Product Description Katherine Bushby and Louise Anderson assemble an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is highly detailed to ensure success and is presented by a hands-on expert. The various DNA techniques focus on both the X-linked muscular dystrophies and the autosomal recessive muscular dystrophies. The protein methods include expression analysis, multiplex western blot analysis, immunocytochemical analysis, and reviews of immunological reagents and of amplification systems. Comprehensive and highly practical, Muscular Dystrophy: Methods and Protocols offers today's diagnostic laboratories, basic and medical researchers, and clinicians an authoritative collection of tools that will serve as exacting diagnostic tools as well as greatly empowering research on the novel therapeutics now beginning to emerge. Muscular Dystrophy: Methods and Protocols (Methods in Molecular Medicine) (Methods in Molecular... Available from Amazon Price: $125.00 Updated on 9-5-2008.

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