Colonic Diseases by Timothy R. Koch Sales Rank: 3244747 List Price: $175.00 $145.00 At Amazon on 10-16-2008.

Hardcover: 572 pages Publisher: Humana Press; 1 edition April 30, 2003 Language: English ISBN-10: 0896039617 ISBN-13: 978-0896039612 Product Dimensions: 10 x 7.3 x 1.1 inches Shipping Weight: 3 pounds From the New England Journal of Medicine, January 22, 2004 Most books that come my way these days end up on a shelf gathering dust and are seldom if ever consulted after an initial inspection. For many clinicians and basic scientists, the preferred method of retrieving information and reference data is with the use of a computer terminal. At first glance, I assumed the book edited by Koch would probably have a fate similar to that of the rest of my office library. But no. Here is a collection of chapters that I will recommend for use by trainee clinician-scientists and by basic scientists who desire a perspective on their work -- a bridge between basic and clinical research. Providing such a bridge is the main objective of this book. To that end, it succeeds admirably. The book is an attractive, high-quality production, well illustrated and comprehensively referenced. Despite its title, only about a third of the book deals with a description of colonic diseases; the remainder deals with aspects of colonic physiology and the investigation into disease processes. Most of the authors of the 33 chapters are widely recognized for their expertise and contributions. This expertise is reflected in the writing, which is generally succinct, clear, and of a high standard. (Figure) Although this collection includes chapters that one expects to find in traditional textbooks, it also covers topics that are more difficult to find in such books. For example, the chapter on the interpretation of colonic biopsies will be useful to many readers and is likely to help improve communication between clinicians and pathologists. Similarly, an entire chapter dedicated to epidemiologic studies and outcomes research will be of use to clinical and scientific readers whether they are conducting research or attempting to interpret it. A chapter on the physiology and pathophysiology of colorectal sensory processes provides an anchoring perspective for subsequent chapters on disease processes such as irritable bowel syndrome. Other useful information that is often buried in large, conventional textbooks is covered in chapters dedicated to colonic lymphatics, aging, and mucins. Most of the information is current, although I was disappointed by some omissions. The chapter on Crohn's disease should have included current information on the NOD2/CARD15 mutation, and the chapters on immunology and inflammation would benefit from a better discussion of the innate immune system and Toll-like receptors. Notwithstanding such notable drawbacks, the book provides the reader with a crisp, readable account of the contribution of basic scientific endeavor to modern gastroenterology. That gastroenterology in general and colorectal physiology and pathophysiology in particular have emerged as exciting fields that are rich with scientific advances at both the research bench and the bedside is well illustrated in this book. For those in the field of colonic disorders who have become jaded by the use of unwieldy textbooks and computer terminals, this book is refreshingly manageable, easy to read, and generally filled with useful information. Fergus Shanahan, M.D. Copyright © 2004 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS. Product Review "recommended for use by trainee clinician-scientists and by basic scientists who desire a perspective on their work-a bridge between basic and clinical researchan attractive, high-quality production, well illustrated and comprehensively referencedrefreshingly manageable, easy to read, and generally filled with useful information." - New England Journal of Medicine "The book contains brief, generally well-written chapters surveying a wide range of topics of interest to most gastroenterologists. Dedicated chapters not found in most gastoenterology textbooks include coverage of aging and the gastrointestinal tract and the interpretation of colonic biopsy specimens in patients with diarrhea." - American College of Physicians "Valuable reading for gastroenterologists interested in bridging the gap between basic and clinical research and disease processes in the continuously changing field of coloni c disorders." - Digestive and Liver Disease "this textbook has its greatest value for those interested in the basics of colonic morphology and functionChapters on anorectal and colonic motility studies are probably among the best I have ever read on these subjects." - Practical Gastroenterology "The book is well organized and written clearly with many references helpful to the reader seeking additional knowledge on the subject. This book is mostly intended for gastroenterologists, gastrointestinal fellows, all specialist physicians including radiologists and family physicians who daily treat gastrointestinal disorders." - Journal of Clinical Imaging Colonic Diseases Available from Amazon Price: $145.00 Updated on 10-16-2008.

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