Cardiac Markers (Pathology and Laboratory Medicine) (Pathology and Laboratory Medicine) by Alan H. B. Wu Sales Rank: 1945402 List Price: $150.00 $132.74 At Amazon on 10-16-2008.

Hardcover: 488 pages Publisher: Humana Press; 2 edition June 12, 2003 Language: English ISBN-10: 1588290360 ISBN-13: 978-1588290366 Product Dimensions: 10.2 x 7.2 x 1.3 inches Shipping Weight: 2.6 pounds From The New England Journal of Medicine, December 24, 1998 For a cardiologist, reviewing Cardiac Markers, written predominantly by and for clinical biochemists, feels uncomfortably like reading someone else's diary. However, the nature of this book's subject will encourage prying eyes. The inadequacy of clinical acumen, gravitas, and a long stethoscope in diagnosing acute coronary syndromes is a disappointing fact of life, and the blood test has long been enshrined in the World Health Organization's definition of acute myocardial infarction. Recent advances in noninvasive and invasive treatments of acute coronary syndromes depend on early and rapid diagnosis. For this reason, considerable energy and resources have been channeled into the quest for the "perfect" test of myocardial injury. The numerous markers that have emerged from this frenetic research, as well as the incorporation of these markers into new prognostic and therapeutic algorithms, has meant that the need to understand this rapidly evolving field is not confined to the clinical laboratory. This book will therefore appeal to a wider readership than its intended audience. The book is simple in layout. The first of four sections consists primarily of an overview of acute coronary syndromes and their management and ends with a chapter on the ultrastructure of the striated-muscle cell. The second and third sections deal with cardiac markers of the past, present, and future, beginning with cytosolic enzymes and ending with sarcomeric proteins. The final section addresses the future clinical role of cardiac markers, with an entire chapter devoted to the regulation and feasibility of point-of-care testing. Most of the chapters are concise and well illustrated. Particularly informative are the chapters on troponins and creatine kinase, arguably the most important of the markers discussed. These chapters are written and illustrated in such a way that the methods and limitations of the assays can be readily appreciated by biochemists and clinicians alike. One interesting concept that emerges from these chapters is the potential application of cardiac markers beyond the diagnosis of acute coronary syndromes: from the stratification of risk in cardiac failure to the diagnosis of cardiac-transplant rejection. As the sensitivity and specificity increase, the detection of inflammatory damage to myocytes is likely to have an effect on the diagnosis and management of these and related conditions, including cardiomyopathies. One of the casualties of the information age is the coherent, single-author medical book. Despite its relatively narrow subject, this book boasts no fewer than 15 contributors, with a consequent lack of uniformity in style and presentation and some overlap among chapters. The final chapter includes brief sections on C-reactive protein in atheroma and on functional imaging in the diagnosis of coronary disease. These discussions seem out of place. The lack of a concluding overview of the markers discussed earlier in the book and their probable future role in the clinical arena contributes to a slightly disjointed quality of the book, although a brief overview can be found in the editor's preface. These cosmetic comments notwithstanding, this short book addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the bookshelves of clinical pathologists, emergency physicians, and cardiologists. Reviewed by Niall G. Mahon, M.D. Copyright © 1998 Massachusetts Medical Society. All rights reserved. The New England Journal of Medicine is a registered trademark of the MMS. --This text refers to the Hardcover edition. Product Review "addresses the need in a variety of disciplines for an understanding of the evolving role of cardiac markers, particularly in relation to the diagnosis and treatment of acute coronary syndromes. The book provides a concise and informative summary of a rapidly developing field and will be a useful addition to the book-shelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine "a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical applicationhighly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal "This comprehensive book not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratories with detailed information on the new markers which are now becoming standard." - Clinical Laboratory International "highly recommended as a reference resource for cardiologists, internists, emergency medicine physicians, and laboratory medicine physicians who have specific questions regarding the many clinically relevant cardiac markerswill save the physician considerable time and effort in answering a specific question that he or she may have within this rapidly evolving field." - Texas Heart Institute Journal From reviews of the first edition "provides a concise and informative summary of a rapidly developing field and will be a useful addition to the bookshelves of clinical pathologists, emergency physicians, and cardiologists." -New England Journal of Medicine "a valuable addition to the compendium of laboratory medicine literature on diagnostic tests and their appropriate clinical applicationhighly recommended for any individual interested in the state-of-the-art of appropriate laboratory assessment of the acute coronary syndrome patient." -Doody's Health Sciences Book Review Journal Cardiac Markers (Pathology and Laboratory Medicine) (Pathology and Laboratory Medicine) Available from Amazon Price: $132.74 Updated on 10-16-2008.

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